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Innate Immunity and Tissue Repair

Tissue damage is almost always followed by an immune response. This first response involves components of the innate immune system; neutrophils are the first cells to arrive at the injured site, followed by extravasated monocytes differentiating to macrophages. Together with the tissue resident macrophages, recruited macrophages actively regulate the tissue healing process. Controlling these and other cells and components from the innate immune system seems therefore promising in bringing regenerative medicine to a next level and creating new strategies and approaches.

The aim of this issue is to highlight original research focused on diverse approaches to define the role of innate immunity in tissue regeneration. Original studies that test the efficacy of targeting the innate immune system to improve tissue regeneration are also encouraged. Topics include, but are not limited to, effector molecules, cells, and cytokines of innate immunity involved in relation to in tissue growth, repair, and regeneration. Submissions should demonstrate a clear focus on innate immune system mediators in the study aims and/or outcomes.

Dr Yvonne Bastiaansen-Jenniskens

Guest Editor


innate immune system

tissue regeneration




mast cells

dendritic cells


Submission Deadline: 15 November 2019

Online Submission

Manuscripts should be submitted online through Hapres Online Submission System. Please visit Guide for Authors before submitting a manuscript. Authors are encouraged to submit a paper as soon as it is ready and don’t need to wait until the deadline. Submissions will be sent to peer-review in order of arrival. Accepted papers will be published continuously in Regenerative Medicine Frontiers (RMF) and then gathered together on the special issue webpage. We welcome Research articles, Review papers and Short Communications. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.


Virtual Special Issue (VSI) is a collection of papers centered around a specific topic, led by an expert (Guest Editor) in the field. Virtual Special Issues are an important component of our journal and cover current hot topics within the scope of the journal.

All papers belonging to a Virtual Special Issue will be gathered together on a single webpage. They are published in the regular issues of the journal as soon as publishable, and labeled as belonging to the Virtual Special Issue. A link from each paper will take you to the Virtual Special Issue website.

Submissions to Virtual Special Issues will undergo the same rigorous peer-review process as regular papers submitted to the journal.

Guest Editor

  • Dr. Yvonne Bastiaansen-Jenniskens

    Assistant professor in Macrophages in the Osteoarthritic knee
    Department of Orthopedics, Erasmus MC, University Medical Center, Rotterdam, The Netherlands

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